Cytochrome P-450 CYP1A1

A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.

Also Known As:

CYP1A1; EROD; 7-Ethoxyresorufin O-Deethylase; CYP 1A1; CYP1A1 Protein; Cytochrome P450 IA1; Ethoxyresorufin Dealkylase; Ethylresorufin O-Deethylase; Cytochrome P 450 CYP1A1; Ethoxyresorufin O-Deethylase

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Oxidoreductases: 13899
    - Oxygenases: 336
      - Mixed Function Oxygenases: 2207
        Cytochrome P-450 Enzyme System: 5452
        Cytochrome P450 Family 1: 71
        Cytochrome P-450 CYP1A1: 2184
        Aryl Hydrocarbon Hydroxylases: 18
        Cytochrome P-450 CYP1A1: 2184
- Cytochromes: 2210
  - Cytochrome P-450 Enzyme System: 5452
    - Cytochrome P450 Family 1: 71
      - Cytochrome P-450 CYP1A1: 2184
    - Aryl Hydrocarbon Hydroxylases: 18
      - Cytochrome P-450 CYP1A1: 2184
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Hemeproteins: 196
    - Cytochromes: 2210
      - Cytochrome P-450 Enzyme System: 5452
        Cytochrome P450 Family 1: 71
        Cytochrome P-450 CYP1A1: 2184
        Aryl Hydrocarbon Hydroxylases: 18
        Cytochrome P-450 CYP1A1: 2184

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Disease

Drug/Important Bio-Agent (IBA)